4/1/2024 0 Comments Rat hippocampus anatomy ca1Significant differences were found in the fraction of reactive microglia which was 40% of total in adult, 33% in aged and 50% in LPS-treated rats. Radiatum, often in association with apoptotic cells. Reactive microglia were present in the CA1 Str. Cellular debris, which were more numerous in CA1 of aged and LPS-treated rats, could be found apposed to astrocytes processes and were phagocytated by reactive microglia. Astrocyte branches infiltrated apoptotic neurons of aged and LPS-treated rats. radiatum of aged rats in comparison to adult and LPS-treated rats. Astrocytes were smaller, with thicker and shorter branches and less numerous in CA1 Str. In the present study we examined the effect of normal ageing and LPS-induced inflammation on astroglia-neuron interaction in the rat hippocampus of adult, normal aged and LPS-treated adult rats. The hippocampus is one of the structures more closely related to electrophysiological, structural and morphological changes during ageing. The association between inflammation and ageing is based on complex molecular and cellular changes that we are only just beginning to understand. Ageing is accompanied by a decline in cognitive functions along with a variety of neurobiological changes.
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